Evidence map›Paper›PMID 42074033›Full record

SynthesisInternational journal of molecular sciences2026

The Prognostic Value of Pre-Procedural and Post-Procedural Inflammatory-Oxidative Stress Biomarkers in Acute Coronary Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Jonathan Samuel Matogu Tambunan, Citrawati Dyah Kencono Wungu, Hendri Susilo, Azizah Bonitha Zahrah Santoso, Anindita Azkia Fauzana, Pramudya Dhafa Hernandi, Albert Steven Purnama, Langgeng Agung Waskito, Indah Mohd Amin, Nando Reza Pratama

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan Samuel Matogu TambunanFaculty of Medicine, Medical Program, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0009-0005-3210-0641
Citrawati Dyah Kencono WunguDepartment of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0000-0001-5180-957X
Hendri SusiloCardiovascular and Cardiometabolic Science Research Group, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0000-0002-5603-9487
Azizah Bonitha Zahrah SantosoFaculty of Medicine, Medical Program, Universitas Airlangga, Surabaya 60132, Indonesia.
Anindita Azkia FauzanaFaculty of Medicine, Medical Program, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0009-0008-0317-7377
Pramudya Dhafa HernandiFaculty of Medicine, Medical Program, Universitas Airlangga, Surabaya 60132, Indonesia.
Albert Steven PurnamaFaculty of Medicine, Medical Program, Universitas Airlangga, Surabaya 60132, Indonesia.
Langgeng Agung WaskitoDepartment of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.ORCID 0000-0002-9400-1973
Indah Mohd AminFaculty of Dentistry, Universiti Teknologi MARA, Selangor 47000, Malaysia.
Nando Reza PratamaNuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Funding

Indonesia Endowment Fund for Education Contract No. 297/UN3/HK.07.00/2025Indonesia Endowment Fund for Education Contract No. 4300/B3/DT.03.08/2025International Research Collaboration Top Tier Scheme No.5418/B/UN3.LPPM/PT.01.03/2025
6 · The paper itself

Abstract

Acute coronary syndrome patients undergoing percutaneous coronary intervention remain at high risk for major adverse cardiovascular events (MACE: cardiovascular mortality, non-fatal myocardial infarction, and stroke). Inflammatory-oxidative stress biomarkers are potential prognostic tools; however, the influence of sampling timing-pre-procedural versus post-procedural-remains unclear. This meta-analysis evaluated six biomarkers: sST2, GDF-15, OPG, sLOX-1, H-FABP, and Galectin-3. Pooled Hazard Ratios (HRs) for time-to-event outcomes and Standardized Mean Differences (SMDs) between event and non-event groups were synthesized using random-effects models involving 40 studies (18,933 patients). Elevated pre-procedural levels of sST2 (HR = 3.32,

Indexed as

Acute Coronary SyndromeBiomarkersInflammationOxidative StressPercutaneous Coronary InterventionGrowth Differentiation Factor 15HumansPrognosisBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15acute coronary syndromebiomarkerscardiovascular diseasesGDF-15oxidative stresspercutaneous coronary interventionprognosissST2

Identifiers

PMID42074033
PMCPMC13115952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.