Genome-Wide Association Study of Genetic Variants Associated with Lower Extremity Amputation Risk in Peripheral Artery Disease.

Rajashekar Korutla, Tanisha Garg, Michael P Wilczek, Elsie G Ross, Saeed Amal

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rajashekar KorutlaCollege of Engineering, The Roux Institute, Northeastern University, Portland, ME 04101, USA.ORCID 0009-0001-2071-5236

Tanisha GargCollege of Science, The Roux Institute, Northeastern University, Portland, ME 04101, USA.

Michael P WilczekCollege of Science, The Roux Institute, Northeastern University, Portland, ME 04101, USA.

Elsie G RossDepartment of Surgery, Division of Vascular Surgery, San Diego School of Medicine, University of California, La Jolla, San Diego, CA 92037, USA.ORCID 0000-0002-9366-0109

Saeed AmalCollege of Engineering, The Roux Institute, Northeastern University, Portland, ME 04101, USA.ORCID 0000-0001-8703-6986

Funding

Artificial Intelligence for early Detection of Peripheral Artery Disease (AID-PAD)R01AG084343 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elsie Gyang Ross · 2023 to 2026

$2.1M

NIA NIH HHS R01 AG084343

6 · The paper itself

Abstract

Peripheral artery disease (PAD) is a global health burden affecting over 200 million individuals and is frequently complicated by limb-threatening ischemia, leading to major amputations. Despite known clinical risk factors, the genetic basis underlying amputation risk in PAD remains poorly defined. In this study, we performed a multi-pronged genome-wide association study (GWAS) to identify genetic variants associated with lower extremity amputation in patients with PAD, using data from the

Indexed as

Amputation, SurgicalGenetic Predisposition to DiseaseGenome-Wide Association StudyLower ExtremityPeripheral Arterial DiseasePolymorphism, Single NucleotideAgedFemaleGene FrequencyGenetic VariationHumansMaleRisk FactorsamputationFirth correctiongenetic risk factorsgenome-wide association studyperipheral artery diseasesingle nucleotide polymorphisms

Identifiers

PMID42074049

DOI10.3390/ijms27083405

PMCPMC13115880

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.