Evidence mapPaperPMID 42074201Full record

ArticleInternational journal of molecular sciences2026

Drug Repurposing Uncovers New Chemical Scaffolds as Potent Urease Inhibitors: A Comprehensive Computational Study.

Sofía E Ríos-Rozas, Elizabeth Valdés-Muñoz, Vicente Rojas-Santander, Javier Farías-Abarca, Erix W Hernández-Rodríguez, Héctor R Contreras, Jonathan M Palma, Reynier Suardíaz, Manuel I Osorio, Osvaldo Yáñez and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sofía E Ríos-RozasLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.ORCID 0009-0003-4907-3964
Elizabeth Valdés-MuñozLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.
Vicente Rojas-SantanderLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.
Javier Farías-AbarcaLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.ORCID 0009-0006-1828-4656
Erix W Hernández-RodríguezLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.ORCID 0000-0002-9231-7552
Héctor R ContrerasBasic and Clinical Oncology Department, Faculty of Medicine, University of Chile, Santiago 8350499, Chile.ORCID 0000-0003-4012-2662
Jonathan M PalmaFacultad de Ingeniería, Universidad de Talca, Curicó 3349001, Maule, Chile.
Reynier SuardíazDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-1035-9020
Manuel I OsorioFacultad de Odontología, Universidad Andrés Bello, Santiago Chile, Echaurren 237, Santiago 8370133, Chile.ORCID 0000-0002-1297-8351
Osvaldo YáñezCentro de Modelación Ambiental y Dinámica de Sistemas (CEMADIS), Facultad de Ingeniería y Negocios, Universidad de Las Américas, Santiago 7500975, Chile.ORCID 0000-0001-8993-9353
Luis Morales-QuintanaMultidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biomédicas, Facultad de Ciencias de La Salud, Universidad Autónoma de Chile, Cinco Poniente #1670, Talca 7500912, Región del Maule, Chile.ORCID 0000-0002-7194-1989
Daniel BustosLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3480094, Chile.ORCID 0000-0002-2136-2305

Funding

Agencia Nacional de Investigación y Desarrollo FONDECYT de Iniciación #11230033Agencia Nacional de Investigación y Desarrollo FONDECYT project 1251871Agencia Nacional de Investigación y Desarrollo FONDECYT Regular #1241305Agencia Nacional de Investigación y Desarrollo FONDECYT Regular #1250346Agencia Nacional de Investigación y Desarrollo FONDECYT Regular project #1260886 and FOVI230136NLHPC CCSS210001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug RepositioningEnzyme InhibitorsHelicobacter pyloriUreaseLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingThermodynamicsEnzyme InhibitorsLigandsUreaseconsensus dockingdrug-repurposingmetadynamicsureasevirtual screening

Identifiers

PMID42074201
PMCPMC13115936

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.