ArticleInternational journal of molecular sciences2026
Association Between Maternal Gestational Diabetes, Cord Blood DNA Methylation, and Offspring Neurodevelopment.
Nieves Luisa González-González, Marina Armas-González, Enrique González-Dávila, José Ramón Castro-Conde, Candelaria González-Campo, Carlos Flores, José Miguel Lorenzo-Salazar, Rafaela González-Montelongo, Adrián Muñoz-Barrera, Erika Padrón-Pérez and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
12 authors.
Nieves Luisa González-GonzálezDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.ORCID 0000-0003-1401-5580 Marina Armas-GonzálezDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.
Enrique González-DávilaDepartment of Mathematics, Statistics and Operations Research, Instituto de Matemáticas y Aplicaciones (IMAULL), University of La Laguna (ULL), 38320 La Laguna, Spain.ORCID 0000-0002-0781-9161 José Ramón Castro-CondeDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.ORCID 0000-0003-0867-2920 Candelaria González-CampoDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.
Carlos FloresResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, Instituto de Investigación Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain.ORCID 0000-0001-5352-069X José Miguel Lorenzo-SalazarGenomics Division, Instituto Tecnológico y de Energías Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain.ORCID 0000-0002-5135-2861 Rafaela González-MontelongoGenomics Division, Instituto Tecnológico y de Energías Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain.ORCID 0000-0001-9022-8663 Adrián Muñoz-BarreraGenomics Division, Instituto Tecnológico y de Energías Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain.ORCID 0000-0002-1561-5898 Erika Padrón-PérezDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.ORCID 0000-0001-5243-3244 Laura Tascón-PadrónDepartment of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-9941-9001 Olivia Orribo-MoralesDepartment of Obstetrics and Gynecology, Sección de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain.
Funding
European Regional Development Funds, "A way of making Europe" from the EU-Instituto Tecnológico de Energías Renovables de Tenerife (OA23/043);Instituto de Salud Carlos III (PI18/01700)Ministerio de Ciencia e Innovación (RTC-2017-6471-1; AEI/FEDER)
6 · The paper itselfAbstract
The link between neurodevelopment in infants exposed to maternal gestational diabetes mellitus (GDM) and fetal DNA methylation remains unexplored. We conducted this hypothesis-generating study to investigate the association between fetal DNA methylation and neurodevelopmental outcomes in children of mothers with GDM. We carried out a prospective, observational pilot cohort study comparing infants exposed to maternal GDM with an unexposed control group. Umbilical cord blood DNA methylation was assessed using targeted methylome sequencing covering 3.34 million CpG sites. Infant neurodevelopment was evaluated at age two years using the Bayley-III Scales. Bioinformatics processing identified differentially methylated regions (DMRs), followed by multiple enrichment analyses of DMR-associated genes and partial correlation analyses. Multi-dimensional enrichment analysis of the 1053 identified DMR-associated genes revealed a significant convergence of pathways related to neurogenesis, synaptic components, and axonal guidance. Infants born to mothers with GDM exhibited lower scores in cognitive, language, and motor domains, which were associated with identifiable DNA methylation signatures at birth. Significant correlations were observed in genes essential for brain scaffolding and synaptic circuitry, most notably
Indexed as
Diabetes, GestationalDNA MethylationFetal BloodPrenatal Exposure Delayed EffectsAdultChild, PreschoolCpG IslandsDevelopmental Origins of Health and DiseaseEpigenesis, GeneticFemaleHumansInfantInfant, NewbornMaleNeurodevelopmentPilot ProjectsBayley-IIIcord bloodDNA methylationepigeneticfetal programminggenesgestational diabetes mellitus (GDM)neurodevelopmentwhole-genome bisulfite sequencing (WGBS)
Identifiers
PMID42074209
PMCPMC13115854
What Socratic holds
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