Evidence map›Paper›PMID 42074576›Full record

ArticleGenes2026

Integrative Analysis and Experimental Validation Identify Potential m6A-Related Biomarkers for Osteoporosis.

Zhenyang Wang, Yongqin Chen, Yuxuan Yang, Biteng Xu, Xiejia Jiao, Lei Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhenyang WangDepartment of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China.
Yongqin ChenDepartment of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China.
Yuxuan YangDepartment of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China.
Biteng XuDepartment of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China.
Xiejia JiaoDepartment of Orthopaedics, The Second Qilu Hospital of Shandong University, Jinan 250012, China.
Lei QiDepartment of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China.

Funding

Natural Science Foundation of Shandong Province ZR2024ZD23
6 · The paper itself

Abstract

backgroundThis study investigates the role of N6-methyladenosine (m6A) regulators in osteoporosis (OP) and their interplay with the immune microenvironment, aiming to identify potential m6A-related biomarkers for OP risk assessment and treatment.

methodsTranscriptomic data from GEO datasets were analyzed for differential expression of 22 m6A regulators and immune infiltration patterns. Consensus clustering and m6Ascore grouping defined molecular subtypes, while machine learning algorithms identified potential biomarkers, leading to the construction and validation of a nomogram. Experimental validation involved peripheral blood monocytes (PBMCs) transcriptome sequencing and Western blot of bone tissue.

results

conclusionsThis study establishes a potential m6A-related biomarker signature for OP and provides multi-level experimental evidence that

Indexed as

AdenosineOsteoporosisAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkersEpitranscriptomeGene Expression ProfilingHumansMesenchymal Stem CellsMethyltransferasesRNA-Binding ProteinsRNA MethylationTranscriptomeAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiomarkersFTO protein, humanMethyltransferasesN-methyladenosineRNA-Binding ProteinsYTHDF2 protein, humanimmune microenvironmentm6A regulatorsosteoporosisRNA sequencingWestern blot

Identifiers

PMID42074576
PMCPMC13115835

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.