Evidence map›Paper›PMID 42075834›Full record

ArticlePharmaceuticals (Basel, Switzerland)2026

Esculetin Attenuates Inflammation and Fibrosis to Prevent AKI-to-CKD Transition in Adenine-Induced Renal Injury by Inhibiting the EGFR/SRC/PI3K/AKT/NF-κB Signaling Axis.

Jianglong Chen, Bin Xia, Rujie Zhou, Yunfei Cui, Yu Zhu, Meijia Chen, Jinhua Su, Jinhui Wang, Guang Li

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianglong ChenCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150006, China.ORCID 0009-0008-7299-3140
Bin XiaYunnan Key Laboratory of Southern Medicine Utilization, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.
Rujie ZhouCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150006, China.
Yunfei CuiYunnan Key Laboratory of Southern Medicine Utilization, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.
Yu ZhuYunnan Key Laboratory of Southern Medicine Utilization, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.
Meijia ChenYunnan Key Laboratory of Southern Medicine Utilization, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.
Jinhua SuXishuangbanna Dai Autonomous Prefecture Institute of Drug Supervision and Inspection, Jinghong 666100, China.
Jinhui WangXishuangbanna Dai Medicine Research Institute Co., Ltd., Jinghong 666100, China.
Guang LiYunnan Key Laboratory of Southern Medicine Utilization, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.

Funding

Chinese Academy of Medical Sciences & Peking Union Medical College 2021-I2M-1-031Yunnan Provincial Department of Science and Technology 202402AA310041Yunnan Provincial Department of Science and Technology 202404BI090001Yunnan Provincial Department of Science and Technology 202405AF140073
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AKI-to-CKD transitionchronic kidney diseaseesculetinnetwork pharmacologyNF-κBprophylactic interventiontranscriptomics

Identifiers

PMID42075834
PMCPMC13118383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.