ArticleCurrent developments in nutrition2026
Inflammation Does Not Mediate Relationships between BMI/BMI-for-Age
Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The extent to which inflammation from overweight or obesity influences interpretation of commonly used vitamin A status biomarkers is uncertain. Objectives: We examined relationships among weight status, inflammation, and retinol or retinol-binding protein (RBP) among women (15-49 y) and children (6-59 mo) with normal weight to overweight or obesity. Methods: Cross-sectional data were separately analyzed from 24 surveys representing 24 countries ( Results: Among women, BMI was positively associated with retinol/RBP in 5 of 13 surveys and positively associated with CRP and/or AGP in 10 of 13 surveys; associations between biomarkers of inflammation and retinol/RBP varied in direction and magnitude. Among children, BAZ was positively associated with retinol/RBP in 3 of 22 surveys and positively associated with CRP in 1 survey (none with AGP); inflammation biomarkers were consistently negatively associated with retinol/RBP. In 3 of 13 women's surveys and 1 of 22 children's surveys, inflammation partially mediated the relationship between BMI/BAZ and retinol/RBP; however, the direction of associations varied. Conclusions: In these surveys limited to individuals without undernutrition or malaria, inflammation associated with overweight or obesity does not appear to impact vitamin A assessment when measured with retinol/RBP. However, findings support measurement of biomarkers reflecting inflammation (of any source) to interpret vitamin A status, particularly among children.
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