Evidence map›Paper›PMID 42077263›Full record

ArticleLife metabolism2026

Age-specific effects of hemoglobin A1c, blood pressure, and cholesterol levels on incident cardiovascular diseases among adults with diabetes in China: a 10-year prospective cohort study.

Yue Yin, Xiaojing Jia, Shengli Wu, Hong Qiao, Guijun Qin, Tiange Wang, Chunyan Hu, Hong Lin, Shuangyuan Wang, Yu Xu and 37 more

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Article in Life metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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47 authors.

Yue YinDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiaojing JiaDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shengli WuDepartment of Endocrine and Metabolic Diseases, Karamay Municipal People's Hospital, Karamay, Xinjiang 834000, China.
Hong QiaoDepartment of Endocrine and Metabolic Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Guijun QinDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.ORCID https://orcid.org/0000-0002-2503-7534
Tiange WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-0723-489X
Chunyan HuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Hong LinDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shuangyuan WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yu XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Mian LiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Min XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-3930-8718
Jie ZhengDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-4265-6695
Xiadi HeDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yingfen QinDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Xulei TangDepartment of Endocrine and Metabolic Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China.
Ruying HuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China.
Lixin ShiDepartment of Endocrine and Metabolic Diseases, The Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China.
Qing SuDepartment of Endocrine and Metabolic Diseases, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Xuefeng YuDepartment of Endocrine and Metabolic Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Li YanDepartment of Endocrine and Metabolic Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.
Qin WanDepartment of Endocrine and Metabolic Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Gang ChenDepartment of Endocrine and Metabolic Diseases, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350003, China.ORCID https://orcid.org/0000-0002-8105-2384
Zhengnan GaoDepartment of Endocrine and Metabolic Diseases, Central Hospital of Dalian University of Technology, Dalian, Liaoning 116033, China.
Guixia WangDepartment of Endocrine and Metabolic Diseases, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Feixia ShenDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xuejiang GuDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zuojie LuoDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Li ChenDepartment of Endocrine and Metabolic Diseases, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xinguo HouDepartment of Endocrine and Metabolic Diseases, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Yanan HuoDepartment of Endocrine and Metabolic Diseases, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China.
Qiang LiDepartment of Endocrine and Metabolic Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Yinfei ZhangDepartment of Endocrine and Metabolic Diseases, Central Hospital of Shanghai Jiading District, Shanghai 201800, China.
Tianshu ZengDepartment of Endocrine and Metabolic Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.ORCID https://orcid.org/0000-0001-9171-7151
Chao LiuDepartment of Endocrine and Metabolic Diseases, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, Jiangsu 210028, China.
Youmin WangDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Tao YangDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.ORCID https://orcid.org/0000-0001-6375-3622
Huacong DengDepartment of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Lulu ChenDepartment of Endocrine and Metabolic Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Jiajun ZhaoDepartment of Endocrine and Metabolic Diseases, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, China.ORCID https://orcid.org/0000-0003-3267-9292
Yiming MuDepartment of Endocrine and Metabolic Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-5754-7635
Yuhong ChenDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jieli LuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-1317-0896
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0001-6027-3084
Yufang BiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-4829-5915

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimal control of hemoglobin A1c (HbA1c), blood pressure, and cholesterol (ABC risk factors) is essential for reducing cardiovascular disease (CVD) risk in individuals with diabetes. However, age-specific contributions of these factors remain inadequately characterized. Using data from the China Cardiometabolic Disease and Cancer Cohort study, we assessed the associations between ABC risk factors and incident CVD among Chinese adults with diabetes, stratified by age groups of < 55, 55 to < 65, 65 to < 75, and ≥ 75 years. Cox proportional hazards models and population-attributable fractions (PAFs) were used to quantify the associations between ABC risk factors and incident CVD. During a median follow-up of 10.1 years, 4707 incident cases of CVD were documented. Higher levels of baseline HbA1c, systolic blood pressure (SBP), and low-density lipoprotein cholesterol (LDL-C) were significantly associated with increased CVD risk. Age modified these associations (

Indexed as

cardiovascular diseasediabeteshemoglobinLDL-Csystolic blood pressure

Identifiers

PMID42077263
PMCPMC13134377

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.