ArticleBlood red cells & iron2026
Cost-effectiveness of frontline eltrombopag with immunosuppressive therapy for severe aplastic anemia.
Article in Blood red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
Funding
Abstract
The randomized phase 3 RACE trial demonstrated eltrombopag used in conjunction with traditional immunosuppressive therapy (IST) to be an efficacious treatment for severe aplastic anemia. However, eltrombopag can pose a significant cost burden. Using clinical data from the RACE trial, we performed the first cost-effectiveness analysis of frontline eltrombopag plus IST in adults with newly diagnosed severe aplastic anemia across all accepted willingness-to-pay (WTP) thresholds from the United States modified societal perspective. The primary outcome was the incremental net monetary benefit across WTP thresholds of $50,000-$150,000/quality-adjusted life year (QALY) with base-case WTP threshold of $120,000/QALY. Frontline eltrombopag plus IST versus frontline IST alone accrued discounted costs of $593,000 and $561,000, and discounted QALYs of 11.53 and 10.73, respectively, with a
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