Evidence map›Paper›PMID 42077424›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2026

Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.

Florian Huwyler, Matthias Pfister, Diwakar Phuyal, Yomna E Dean, Margareta Mittendorfer, Lars Saemann, Hannah Rasel, Simon Stoerzer, Jonas Binz, Bahareh Tabatabaei and 5 more

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Florian Huwyler *Hub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Matthias Pfister *Hub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Diwakar PhuyalDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, Cleveland, OH, United States.
Yomna E DeanDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, Cleveland, OH, United States.
Margareta MittendorferDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Lars SaemannDepartment of Cardiac Surgery, University Hospital Halle, Halle, Germany.
Hannah RaselHub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Simon StoerzerHub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Jonas BinzHub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Bahareh TabatabaeiDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, Cleveland, OH, United States.
Gabor SzaboDepartment of Cardiac Surgery, University Hospital Halle, Halle, Germany.
Sandra LindstedtDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Bahar Bassiri GharbDepartment of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, Cleveland, OH, United States.
Mark W TibbittHub for Translational Research and Liver/GI Health, Zurich, Switzerland.
Pierre-Alain ClavienHub for Translational Research and Liver/GI Health, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid advances in tissue preservation and the growing adoption of machine perfusion have fundamentally reshaped solid-organ and tissue transplantation in recent years. Multiple short-term perfusion devices have received regulatory approval and are increasingly used in clinical practice to preserve grafts for several hours, improving allograft assessment. The boundaries of dynamic tissue preservation have been pushed even further in research settings, where grafts have been reliably perfused for multiple days. The extended time of long-term machine perfusion opens a new therapeutic window for interventions, allowing for reconditioning and even tissue repair of injured and diseased grafts. The increasing global organ shortage makes these approaches particularly attractive to recover additional allografts for safe transplantation. In this review, we highlight current clinical practice for

Indexed as

Organ PreservationOrgan TransplantationPerfusionAnimalsHeart TransplantationHumansLung TransplantationTime Factorsheartkidneyliverlungtransplantvascularized composite allografts

Identifiers

PMID42077424
PMCPMC13132794

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.