Evidence map›Paper›PMID 42078335›Full record

ArticlemedRxiv : the preprint server for health sciences2026

CalPred yields calibrated intervals for polygenic risk prediction.

Zhuozheng Shi, Zixuan Eleanor Zhang, Ravi Mandla, Kangcheng Hou, Bogdan Pasaniuc

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhuozheng ShiDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9769-9027
Zixuan Eleanor ZhangDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ravi MandlaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0782-0138
Kangcheng HouDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7110-5596
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9M
Identifying Undiagnosed Alzheimer’s Disease in Understudied PopulationsR01AG085518 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Timothy S Chang · 2024 to 2026
$2.3M
NIA NIH HHS R01 AG085518NIMH NIH HHS R01 MH115676
6 · The paper itself

Abstract

Polygenic scores (PGS) have emerged as a useful biomarker for stratification of high-risk individuals in genomic medicine, with prediction intervals arising as a principled approach to incorporate statistical uncertainty in their individual-level predictions. In contrast to recent reports by Xu et al

Identifiers

PMID42078335
PMCPMC13131751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.