Evidence map›Paper›PMID 42078397›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A loss of function variant in

Marie Gasser, Inès Cherkaoui, Giada Ostinelli, Mathieu Ferron, Qian Du, Dieter Egli, Guy A Rutter

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marie GasserCentre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.ORCID 0000-0002-7242-1141
Inès CherkaouiCentre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.ORCID 0009-0000-3844-4932
Giada OstinelliCentre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.ORCID 0009-0003-5964-2841
Mathieu FerronInstitut de Recherche Clinique de Montréal and Department of Medicine, University of Montreal, Montreal, QC, Canada.ORCID 0000-0002-5858-2686
Qian DuColumbia University, New York, NY, USA.
Dieter EgliColumbia University, New York, NY, USA.ORCID 0000-0002-0812-6412
Guy A RutterCentre Hospitalier de l'Université de Montréal (CHUM) Research Center and Department of Medicine, University of Montreal, Montreal, QC, Canada.ORCID 0000-0001-6360-0343

Funding

Control of insulin secretion by mitochondrial fusionR01DK135268 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brett A Kaufman, Scott Soleimanpour · 2023 to 2026
$2.4M
NIDDK NIH HHS R01 DK135268Wellcome Trust
6 · The paper itself

Abstract

Aims and hypothesis: (1)Loss-of-function mutations in Methods: (2)Human embryonic stem cells INS(GFP/w) (MEL1), and CRISPR/Cas9-derived heterozygous or homozygous R138X lines were differentiated into stem cell-derived islet-like clusters. Intracellular Zn Results: (3)Intracellular Zn Conclusion and interpretation: (4)Intracellular Zn

Indexed as

ApoptosisCalcium signalingCellular protectionR138X mutationSLC30A8Stem cell-derived islet-like clustersTPENType 2 diabetesZinc

Identifiers

PMID42078397
PMCPMC13131851

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.