ArticleFood science & nutrition2026
Protocatechuic Acid Alleviates D-Gal-Induced Renal Senescence and Injury in Mice by Regulating Taurine Metabolism.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protocatechuic acid (PCA), a natural phenolic compound with antioxidant and anti-inflammatory properties, has been proposed as a potential therapeutic agent against aging-related diseases. This study investigated the protective effects of PCA on D-galactose (D-gal)-induced renal aging in mice. PCA administration significantly improved renal function, alleviated oxidative stress and inflammatory responses, and ameliorated histopathological abnormalities. Biochemical analyses revealed reductions in serum AGEs, β-galactosidase, creatinine, and blood urea nitrogen, accompanied by restoration of antioxidant enzyme activities and suppression of proinflammatory cytokines. Transcriptomic and metabolomic profiling further demonstrated that PCA reversed D-gal-induced molecular alterations, with integrated multi-omics analysis identifying taurine and hypotaurine metabolism as the key pathway mediating its renoprotective effects. Western blot validation confirmed that PCA regulates CSAD, an enzyme essential for taurine biosynthesis. Collectively, these findings provide novel mechanistic insights into renal aging and highlight PCA as a promising natural agent for delaying kidney senescence through modulation of taurine metabolism.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.