Evidence map›Paper›PMID 42079247›Full record

ArticlebioRxiv : the preprint server for biology2026

PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential.

A M Coombs, D Heo, D J Orlin, C L Call, M E Bechler, S E Murthy, B Emery, K R Monk

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A M CoombsVollum Institute, Oregon Health & Science University, Portland, OR, USA.
D HeoVollum Institute, Oregon Health & Science University, Portland, OR, USA.
D J OrlinVollum Institute, Oregon Health & Science University, Portland, OR, USA.
C L CallVollum Institute, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0003-2254-4298
M E BechlerDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, USA.
S E MurthyVollum Institute, Oregon Health & Science University, Portland, OR, USA.
B EmeryJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
K R MonkVollum Institute, Oregon Health & Science University, Portland, OR, USA.

Funding

Mechanotransduction Control of CNS Myelin Sheath Length.R01NS135206 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI Marie E Bechler · 2024 to 2026
$1.5M
Molecular and genetic regulation of myelin capacity in the CNSR01NS138188 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Ben Emery, Kelly R Monk · 2025 to 2026
$1.2M
NINDS NIH HHS R01 NS135206NINDS NIH HHS R01 NS138188
6 · The paper itself

Abstract

Myelination requires precise integration of physical cues by oligodendrocyte lineage cells (OLCs), but the molecular sensors that detect these cues remain incompletely understood. Here, we demonstrate that oligodendrocyte progenitor cells (OPCs) are sensitive to sub-micron changes in membrane displacement. Based on channel properties, RNA expression, and protein abundance, we find that the mechanosensitive ion channel PIEZO1 contributes to OPC mechanosensitivity.

Identifiers

PMID42079247
PMCPMC13131812

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.