Evidence map›Paper›PMID 42079400›Full record

ArticleFujita medical journal2026

Association between blood mitochondrial DNA copy number and cognitive function: A cross-sectional study based on the Yakumo Study.

Atsushi Teshigawara, Genki Mizuno, Hiroya Yamada, Yoshiki Tsuboi, Eiji Munetsuna, Yuji Hattori, Mirai Yamazaki, Yoshitaka Ando, Itsuki Kageyama, Takuya Wakasugi and 8 more

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In one paragraph

Article in Fujita medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Atsushi TeshigawaraDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Genki MizunoDepartment of Medical Technology, Tokyo University of Technology School of Health Sciences, Ota, Tokyo, Japan.
Hiroya YamadaDepartment of Hygiene, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yoshiki TsuboiDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Eiji MunetsunaDepartment of Hygiene, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yuji HattoriInternational Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Aichi, Japan.
Mirai YamazakiDepartment of Hygiene, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yoshitaka AndoDepartment of Informative Clinical Medicine, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Itsuki KageyamaDepartment of Hygiene, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Takuya WakasugiDepartment of Hygiene, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Hayato IchikawaDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Hiroshi OkumiyamaDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Ryosuke FujiiDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Akihiko IwaharaDepartment of Psychology and Collaboration, Kyoto Women's University Faculty of Psychology and Collaboration, Kyoto, Kyoto, Japan.
Takeshi HattaDepartment of Health Sciences, Kansai University of Welfare Sciences Faculty of Health and Welfare, Kashiwara, Osaka, Japan.
Hiroaki IshikawaDepartment of Informative Clinical Medicine, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Koji OhashiDepartment of Informative Clinical Medicine, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Koji SuzukiDepartment of Preventive Medical Sciences, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Mitochondrial dysfunction has been implicated in neurodegenerative diseases, but evidence regarding its association with cognitive performance in the general population remains limited. This study aimed to examine the association between peripheral blood mitochondrial DNA copy number (mtDNA-CN) and cognitive function in the general Japanese population. Methods: We conducted a cross-sectional analysis of 282 participants (134 men and 148 women) from the Yakumo Study, a population-based health examination in Hokkaido, Japan. Peripheral blood mtDNA-CN was measured by quantitative real-time PCR and categorized into tertiles. Cognitive function was assessed using the short version of the Mini-Mental State Examination (SMMSE), the Logical Memory Test (LMT), and the Digit Cancellation Test (D-CAT). Logistic regression analyses were performed to evaluate the association between mtDNA-CN levels and cognitive performance, with adjustments for relevant demographic and clinical factors. Results: Lower mtDNA-CN was significantly associated with poorer SMMSE scores in women and with reduced D-CAT3 performance-reflecting attention and executive function-in men. No significant associations were observed for LMT scores in either sex. These domain- and sex-specific associations remained consistent after adjustment for potential confounders. Conclusions: Lower mtDNA-CN was associated with poorer cognitive performance in the general Japanese population, in a cognitive domain- and sex-specific manner. mtDNA-CN thus has potential as a non-invasive biomarker for the early identification of individuals at increased risk of cognitive decline. Longitudinal studies are necessary to evaluate its predictive utility and potential application in dementia prevention strategies.

Indexed as

BiomarkerCognitive functionMitochondriaMitochondrial DNA copy numberPeripheral blood

Identifiers

PMID42079400
PMCPMC13129713

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.