Evidence map›Paper›PMID 42079447›Full record

ArticlemLife2026

The synthetic estradiol analog E0703 enhances

Zhexin Ni, Ziqiao Yan, Mingyang Chang, Yangshuo Li, Zebin Liao, Tiantian Xia, Zhijie Bai, Ningning Wang, Chaoji Huangfu, Dezhi Sun and 7 more

Abstract read
In one paragraph

Article in mLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhexin NiBeijing Institute of Radiation Medicine Beijing China.ORCID https://orcid.org/0000-0002-9723-2398
Ziqiao YanDepartment of Traditional Chinese Medicine The Sixth Medical Center of Chinese People's Liberation Army (PLA) General Hospital Beijing China.
Mingyang ChangBeijing Institute of Radiation Medicine Beijing China.ORCID https://orcid.org/0009-0000-3087-5279
Yangshuo LiDepartment of Traditional Chinese Gynecology The First Affiliated Hospital of Naval Medical University Shanghai China.
Zebin LiaoBeijing Institute of Radiation Medicine Beijing China.
Tiantian XiaBeijing Institute of Radiation Medicine Beijing China.
Zhijie BaiBeijing Institute of Radiation Medicine Beijing China.
Ningning WangBeijing Institute of Radiation Medicine Beijing China.
Chaoji HuangfuBeijing Institute of Radiation Medicine Beijing China.
Dezhi SunBeijing Institute of Radiation Medicine Beijing China.
Yangyi HuBeijing Institute of Radiation Medicine Beijing China.
Liangliang ZhangBeijing Institute of Radiation Medicine Beijing China.
Feiran HaoBeijing Institute of Radiation Medicine Beijing China.
Yongqi DouChinese PLA Medical School, Chinese People's Liberation Army (PLA) General Hospital Beijing China.
Pan ShenBeijing Institute of Radiation Medicine Beijing China.
Wei ZhouBeijing Institute of Radiation Medicine Beijing China.ORCID https://orcid.org/0000-0003-0435-7261
Yue GaoBeijing Institute of Radiation Medicine Beijing China.ORCID https://orcid.org/0000-0003-1131-5326

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of safe and effective radioprotective agents with minimal side effects, particularly for high-dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived from estradiol, has shown promising radioprotective efficacy with limited estrogenic activity in prior pharmacodynamic studies. In this study, E0703 was found to significantly increase the abundance of

Indexed as

acute radiationAkkermansia muciniphilaE0703goblet cells

Identifiers

PMID42079447
PMCPMC13131332

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.