Evidence map›Paper›PMID 42079583›Full record

ArticleFrontiers in immunology2026

Genome-wide association study of atopic and autoimmune comorbidities in alopecia areata.

Marisol Herrera-Rivero, Yasmina Gossmann, Swapnil Awasthi, Nicole Cesarato, Stephan Ripke, Bettina Blaumeiser, Ulrike Blume-Peytavi, Gerhard Lutz, Silke Redler, Markus M Nöthen and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marisol Herrera-Rivero *Department of Genetic Epidemiology, Institute of Human Genetics, and Institute of Epidemiology and Social Medicine, University of Münster; Joint Institute for Individualisation in a Changing Environment (JICE), University of Münster and Bielefeld University, Münster, Germany.
Yasmina Gossmann *Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Swapnil AwasthiDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Nicole CesaratoInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Stephan RipkeDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Bettina BlaumeiserCenter of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium.
Ulrike Blume-PeytaviDepartment of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Gerhard LutzHair and Nail Medicine, Bonn, Germany.
Silke RedlerInstitute of Human Genetics, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Regina C BetzInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
F Buket BasmanavInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alopecia areata (AA) is a chronic autoimmune-mediated disorder characterized by hair loss from the scalp and/or body. AA patients frequently present with comorbid chronic inflammatory disorders (CIDs), particularly atopic and autoimmune diseases. Genome-wide association (GWA) studies have suggested a genetic link. However, no studies to date have examined genetic factors that are associated with the comorbid development of CIDs directly in individuals affected by AA. Methods: We performed an exploratory GWA study in Central European AA patients stratified by self-reported comorbidity status (110 to 1,302 cases with- and 1,030 controls without comorbid CIDs). Comorbidities were analyzed first as broad atopic and autoimmune categories and subsequently as individual conditions, including asthma, atopic dermatitis, rhinitis, vitiligo, and Hashimoto's thyroiditis. Results: No genome-wide significant signals were identified at either the variant or gene level. At exploratory thresholds (p Discussion: Our study provides initial mechanistic insights for comorbid CID development in AA, and a foundation for larger-scale studies.

Indexed as

Alopecia AreataAutoimmune DiseasesGenome-Wide Association StudyHypersensitivityAdultBelgiumComorbidityEuropean PeopleFemaleGenotypeGermanyHumansMaleMiddle Agedalopecia areataautoimmune diseasechronic inflammatory disorderscomorbiditiesgenetics

Identifiers

PMID42079583
PMCPMC13133067

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.