ArticleFrontiers in immunology2026
Increased CD95
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Objective: To investigate the expression patterns of CD95 and CD160 on double-negative T (DN T) cells and their association with incomplete immune reconstitution in people living with HIV. Methods: In this cross-sectional study, people living with HIV (PLWH) receiving long-term antiretroviral therapy (ART) with sustained viral suppression were classified as immunological non-responders (INR) or immunological responders (IR). Flow cytometry was used to characterize double-negative T (DN T) cells and their CD95 Results: The frequency of DN T cells was significantly higher in the INR group than in the IR group (P = 0.022). The frequencies of CD95 Conclusion: Incomplete immune reconstitution in PLWH is associated with phenotypic alterations of DN T cells characterized by increased CD95 and CD160 expression. These findings provide a phenotypic characterization of DN T-cell alterations associated with immune dysregulation in INR and may offer insights for further mechanistic investigation.
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