ReviewFrontiers in immunology2026
Advances in understanding the Th17/Treg balance in systemic lupus erythematosus: implications for treatment and management.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by a complex and multifactorial pathogenesis. Recent studies have highlighted the critical role of the disrupted balance between T helper 17 (Th17) cells and regulatory T (Treg) cells in disease initiation and progression. Understanding this imbalance has offered a conceptual framework for developing novel targeted interventions. In this review, we focus on emerging therapeutic strategies aimed at restoring the Th17/Treg balance. We place particular emphasis on the mechanisms and clinical implications of biologic agents, such as IL-17 inhibitors, IL-6 receptor antagonists, low-dose IL-2, and mammalian target of rapamycin (mTOR) pathway inhibitors. Additionally, we explore cell-based therapies, including chimeric antigen receptor T-cell (CAR-T) and CAR-Treg approaches. We also outline ongoing challenges and potential future directions for translating these findings into precise, immune-modulating treatments for patients with SLE.
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