Evidence map›Paper›PMID 42080342›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Keratinocyte-Mast Cell NF-κB2/CXCL2/IL-6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans.

Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yan YuanJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Manyun MaoJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Jiaan ZhangJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Zhimin DuanJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
JiaNing WangJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Yujie ChenJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Sihan ChenJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Chuting LiangJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Xvyue ZhouJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Songmei GengDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Min LiJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.ORCID https://orcid.org/0000-0003-1330-2326
Xu ChenJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Ni LianJiangsu Provincial Key Laboratory of Dermatology, Institute of Dermatology, Hospital For Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.

Funding

CAMS Innovation Fund for Medical Sciences CIFMS-2021-I2M-1-001National Natural Science Foundation of China 82173432
6 · The paper itself

Abstract

Mast cells (MCs), key innate immune sentinels at the host-environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non-immune cells remain poorly understood. Here, we show that MCs accumulate locally in skin lesions of patients with cutaneous candidiasis. In mouse models, MC-deficient Kit

Indexed as

Candida albicansCandidiasis, CutaneousChemokine CXCL2Interleukin-6KeratinocytesMast CellsNF-kappa BAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLChemokine CXCL2Cxcl2 protein, mouseInterleukin-6NF-kappa Bamplification loopC. albicans infectionkeratinocytesmast cells

Identifiers

PMID42080342
PMCPMC13335439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.