Evidence map›Paper›PMID 42081029›Full record

ArticleAnnals of hematology2026

Haploidentical allogeneic haematopoietic stem cell transplantation for paroxysmal nocturnal haemoglobinuria: a retrospective analysis.

Jing-Yi Bi, Yuan-Yuan Zhang, Hai-Xia Fu, Yun He, Ting-Ting Han, Yao Chen, Zhi-Dong Wang, Jun Kong, Jing-Zhi Wang, Xiao-Dong Mo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jing-Yi BiNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yuan-Yuan ZhangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Hai-Xia FuNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yun HeNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Ting-Ting HanNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yao ChenNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Zhi-Dong WangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Jun KongNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Jing-Zhi WangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Xiao-Dong MoNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yu-Qian SunNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yi-Fei ChengNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yu-Hong ChenNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Yu WangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Xiao-Hui ZhangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Xiao-Jun HuangNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China.
Zheng-Li XuNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China. xuzhengli0202@163.com.
Lan-Ping XuNational Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, P.R. China. lpxu_0415@sina.com.

Funding

National Key Research and Development Program of China 2024YFC2510500
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy and prognostic factors of haploidentical haematopoietic stem cell transplantation (haplo-HSCT) for paroxysmal nocturnal haemoglobinuria (PNH).

methodsWe retrospectively analyzed 36 PNH patients (2 classic PNH, 34 AA-PNH syndrome) undergoing haplo-HSCT (G-CSF/ATG-based protocol) from June 2013 to December 2024, with BU/CY/ATG (n = 28) or BU/CYlow/FLU/ATG (n = 8) conditioning and uniform GVHD prophylaxis.

resultsThe overall myeloid engraftment rate was 100% (median + 12 d) and platelet engraftment rate 95.5% (median + 13 d). Competing risk analysis showed 42.7% acute GVHD (26.7% grade II-IV, 5.3% grade III-IV); 27.3% chronic GVHD (15.2% mild, 12.1% moderate-severe) among 33 evaluable patients. With a median follow-up of 57 months, the 5-year overall survival rate was 88.6 ± 5.4%. All 32 monitored patients achieved PNH clone clearance (median 3 months), 33 had normalized blood counts, and 3 died of infection, organ hemorrhage or pulmonary embolism.

conclusionsHaplo-HSCT yields favorable outcomes and is a curative therapy for PNH, serving as a valuable option for severe bone marrow failure patients, with G-CSF/ATG-based haplo-HSCT as a promising alternative strategy.

Indexed as

Hematopoietic Stem Cell TransplantationHemoglobinuria, ParoxysmalTransplantation, HaploidenticalAdolescentAdultAllograftsFemaleFollow-Up StudiesGraft vs Host DiseaseHumansMaleMiddle AgedRetrospective StudiesSurvival RateTransplantation ConditioningTransplantation, HomologousG-CSF/ATG-based protocolGVHDHaploidentical haematopoietic stem cell transplantationParoxysmal nocturnal haemoglobinuria

Identifiers

PMID42081029
PMCPMC13139281

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.