Evidence map›Paper›PMID 42082825›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2026

The Emerging Role of Interferon-Stimulated Gene 15 (ISG15) in Pregnancy-Related Disorders.

Xiaoxuan Sun, Qingshen Wu, Mingran Zou, Xiaoqing Zhang, Lu Gao

Abstract readReview
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In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoxuan Sun *Department of Physiology, Naval Medical University, Shanghai, 200433, China.
Qingshen Wu *Department of Physiology, Naval Medical University, Shanghai, 200433, China.
Mingran ZouDepartment of Physiology, Naval Medical University, Shanghai, 200433, China.
Xiaoqing ZhangDepartment of Physiology, Naval Medical University, Shanghai, 200433, China. zxq031888@126.com.
Lu GaoDepartment of Physiology, Naval Medical University, Shanghai, 200433, China. roadgao@163.com.ORCID 0000-0003-2170-2645

Funding

Major Project of Shanghai Municipal Education Commission Scientific Research and Innovation Plan 2021-01-07-00-07-E00144National Natural Science Foundation of China 82120108011National Natural Science Foundation of China 82371699National Natural Science Foundation of China 82401998
6 · The paper itself

Abstract

Pregnancy-related disorders, including preterm birth, preeclampsia, recurrent spontaneous abortion, and fetal growth restriction, represent major contributors to global maternal and infant morbidity and mortality. Their pathophysiology involves complex mechanisms such as immune dysregulation, inflammatory responses, oxidative stress, and metabolic disturbances. Interferon-stimulated gene 15 (ISG15), a ubiquitin-like protein, regulates diverse biological processes-including antiviral immunity, cellular metabolism, oxidative stress, and DNA damage response-through ISGylation, which covalently conjugates ISG15 to target proteins. In recent years, the potential role of ISG15 in pregnancy-related diseases has attracted growing interest. This review systematically outlines the molecular characteristics and functions of ISG15, with a focus on its research advances in preeclampsia, recurrent spontaneous abortion, preterm birth, and fetal growth restriction. Furthermore, it discusses the potential of ISG15 as a novel biomarker or therapeutic target for pregnancy-related disorders, providing new insights for early prevention and clinical management. Collectively, this review positions ISG15 as a critical regulator in pregnancy-related pathologies and underscores its translational potential.

Indexed as

CytokinesPregnancy ComplicationsUbiquitinsAnimalsBiomarkersFemaleHumansPregnancyBiomarkersCytokinesISG15 protein, humanUbiquitinsFetal growth restrictionInterferon-stimulated gene 15ISGylation modificationPreeclampsiaPreterm birthRecurrent miscarriage

Identifiers

PMID42082825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.