ArticlePeerJ2026
Androgen promotes oocyte development by upregulating gap junction intercellular communication activity in granulosa cells in mice.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent studies have highlighted the role of androgen in poor ovarian response (POR). However, the mechanisms by which androgen works, particularly in older POR patients, remain unclear. The study aimed to investigate the effects of androgen on granulosa cells and to explore the underlying mechanisms preliminarily. Methods: Elderly female C57BL/6J mice were treated with various concentrations of dehydroepiandrosterone (DHEA) Results: DHEA treatment significantly increased serum DHEA, T, and anti-Müllerian hormone levels, as well as the number of oocytes harvested. Treatment with T within the physiological concentration range significantly increased GJIC activity. These effects of T were partially counteracted by flutamide or GF109203X. Conclusions: Androgen may enhance GJIC activity in granulosa cells
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.