Evidence map›Paper›PMID 42083698›Full record

ArticleCureus2026

Rupatadine as an Add-On Therapy for Dengue Hemorrhagic Fever: A Case Report.

Mauricio E Flores

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Mauricio E FloresPediatrics Allergy and Immunology, Clinica de Asma y Alergias, Santa Elena, SLV.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue hemorrhagic fever (DHF) is a severe form of dengue fever. Plasma leakage is the main pathophysiological hallmark that distinguishes DHF from mild dengue infection, and can result in hypovolemic shock and fatal outcome. No specific drugs and vaccines are available to treat dengue disease, and supportive therapy based on fluid replacement therapy and symptomatic medication (e.g., antipyretic/analgesics) should be promptly instituted. Platelet-activating factor (PAF) is associated with an increase in vascular permeability and has been found to be elevated in patients with DHF, supporting the use of strong PAF antagonists, such as rupatadine, in the management of severe dengue. We here report the case of a 17-year-old female patient presenting with fever, abdominal pain, headache, nausea, transvaginal bleeding, and thrombocytopenia (platelet count 45,000 cells/mm

Indexed as

dengue hemorrhagic fever (dhf)platelet-activating factorrupatadinesupportive therapythrombocytopenia

Identifiers

PMID42083698
PMCPMC13135652

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.