Evidence mapPaperPMID 42084749Full record

ArticleNeuromolecular medicine2026

Enhanced Neurophysiological Benefits of Magnesium-Acetyl-Taurate Over Magnesium-L-Threonate: A Comparative pre-clinical Study on Bioavailability, Synaptic Plasticity and Cognitive Functions.

Aakash Kumar, Sidharth Mehan, Sumedha Gupta, Ghanshyam Das Gupta, Rajaram Samant, Manoj Tongra

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. UntargetedNutrients · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aakash KumarDivision of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India.
Sidharth MehanDivision of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India. sidharthmehan@isfcp.org.ORCID 0000-0003-0034-835X
Sumedha GuptaDivision of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India.
Ghanshyam Das GuptaIK Gujral Punjab Technical University, Jalandhar, 144603, Punjab, India.
Rajaram SamantChief Scientific Officer, Celagenex Research, Mumbai, India.
Manoj TongraChief Scientific Officer, Celagenex Research, Mumbai, India.

Funding

Celagenex Research, CA, USA ISFAL/PH/14/02/23/27
6 · The paper itself

Abstract

The study examines how magnesium compounds, especially Magnesium-L-Threonate (MLT) and Magnesium-Acetyl-Taurate (MAT), affect neurophysiological functions in adult Wistar rats. Magnesium is essential for many cellular processes in the brain & peripheral system, such as neurotransmitter regulation, muscle function, and energy metabolism. Tissue Mg²⁺ levels were defined as the primary endpoint of the study, as they directly reflect the central objective of evaluating magnesium-based interventions. All other outcomes, including behavioral, biochemical, and molecular parameters, were considered secondary endpoints. This research aimed to compare the brain effectiveness of MLT (115 mg/kg and 450 mg/kg) and MAT (150 mg/kg and 500 mg/kg) in raising magnesium levels in biological samples like blood plasma, cerebrospinal fluid (CSF), muscles and brain tissues. The aim is to examine the effect of Magnesium compounds (MLT, MAT & combination treatment) on modulation and alterations in all the biological markers for neuroinflammation, synaptic plasticity, neurotransmission balance, oxidative stress & mitochondrial functioning. MAT showed better Mg

Indexed as

CognitionMagnesium CompoundsNeuronal PlasticityTaurineAnimalsBiological AvailabilityBrainButyratesCognitive EnhancementDrug Evaluation, PreclinicalMagnesiumMaleMaze LearningMitochondriaOxidative StressRatsButyratesMagnesiumMagnesium CompoundsTaurinethreonic acidCognitive enhancementMagnesium-Acetyl-Taurate (MAT)Magnesium-L-Threonate (MLT)Neurophysiological functions

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.