Evidence map›Paper›PMID 42085021›Full record

ArticleThe Journal of experimental medicine2026

TACI regulates marginal zone B cell development.

Daisy H Luff, Lesley Vanes, Stefan Boeing, Victor L J Tybulewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daisy H LuffThe Francis Crick Institute , London, UK.ORCID 0000-0002-9622-664X
Lesley VanesThe Francis Crick Institute , London, UK.ORCID 0000-0003-2868-6078
Stefan BoeingThe Francis Crick Institute , London, UK.ORCID 0000-0003-0495-5659
Victor L J TybulewiczThe Francis Crick Institute , London, UK.ORCID 0000-0003-2439-0798

Funding

Cancer Research UK CC 2080Francis Crick Institute CC 2080UK Medical Research Council CC 2080Wellcome Trust CC 2080
6 · The paper itself

Abstract

The mature B cell compartment consists of follicular and marginal zone (MZ) B cells, which develop from transitional type 2 (T2) B cells. TACI, a member of the TNF receptor superfamily, is expressed on all mature B cells, with highest levels on MZ B cells and plasma cells. Previous studies reported that TACI is a negative regulator of B cell survival. However, this conclusion is confounded by elevated levels of BAFF, a cytokine that supports B cell survival, in TACI-deficient mice. We now show that TACI does not directly regulate B cell survival in mice but rather has a cell-intrinsic role in MZ B cell development. Loss of TACI leads to reduced MZ B cell numbers and an impaired T-independent antibody response. Mechanistically, we show that TACI is required for MZ B cell development from T2 B cell precursors via activation of the PI3K-AKT pathway and subsequent inhibition of the FOXO1 transcription factor.

Indexed as

B-LymphocytesCell DifferentiationTransmembrane Activator and CAML Interactor ProteinAnimalsB-Cell Activating FactorCell SurvivalForkhead Box Protein O1Forkhead Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionB-Cell Activating FactorForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTnfrsf13b protein, mouseTransmembrane Activator and CAML Interactor Protein

Identifiers

PMID42085021
PMCPMC13142658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.