Evidence map›Paper›PMID 42085148›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.

Sangjun Lee, Jimin Park, Ivan Alekseichuk, Taylor A Berger, Ana M G Manea, Harry Tran, Gabriela Delgado Salazar, Seth D König, Alexander B Herman, David P Darrow and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sangjun LeeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-9197-7359
Jimin ParkDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-4943-4673
Ivan AlekseichukStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-2205-4910
Taylor A BergerDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-5331-0016
Ana M G ManeaDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-4786-9657
Harry TranDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0003-2847-151X
Gabriela Delgado SalazarDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455.ORCID 0009-0004-3785-4437
Seth D KönigDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-1600-0342
Alexander B HermanDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-6229-433X
David P DarrowDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-9335-0584
Jan ZimmermannDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-4851-1243

Funding

Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain NetworksRF1MH124909 · NIMH · UNIVERSITY OF MINNESOTA · PI OPITZ, ALEXANDER · 2020 to 2020
$2.4M
Brain and Behavior Research Foundation (BBRF) a NARSAD Young Investigator GrantHHS | NIH | National Institute of Mental Health (NIMH) RF1MH124909University of Minnesota (UMN) Minnesota Partnership for Biotechnology and Medical Genomics (MNP) programUniversity of Minnesota (UMN) MnDRIVE Initiative
6 · The paper itself

Abstract

Cortical traveling waves (TWs) are brain oscillation patterns that support the transfer of neural information across distinct brain regions, with their direction shaping cognitive function. However, direct evidence for their causal influence on brain dynamics and behavior remains lacking. Here, we establish such a causal link by externally applying TW-like electric field patterns. To achieve this, we develop a noninvasive brain stimulation protocol, traveling-wave transcranial alternating current stimulation (twtACS). twtACS can generate a precise directional electric field that propagates across the cortical surface, which we validate using human intracranial recordings. In monkey recordings, we show that neural spiking was directionally modulated, shifting systematically across space in line with the direction of twtACS. In humans, twtACS led to direction-dependent improvements in cognitive performance. Together, these findings demonstrate that externally imposed TWs can causally shape neural activity and cognition, highlighting the potential of twtACS as a neuromodulation technique for cognitive enhancement.

Indexed as

BrainCognitionTranscranial Direct Current StimulationAdultAnimalsCognitive EnhancementFemaleHumansMacaca mulattaMaleNeuronscognitioncortical traveling wavesintracranial recordingsneural timingnoninvasive brain stimulation

Identifiers

PMID42085148
PMCPMC13167727

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.