Evidence map›Paper›PMID 42087331›Full record

ArticleHead & neck2026

Variations in Treatment Prescription and Survival Outcomes Between Older and Younger Patients With Mucosal Head and Neck Squamous Cell Carcinoma Treated With Radiotherapy.

Farhannah Aly, Joseph Descallar, Purnima Sundaresan, Alexis Andrew Miller, Lois Holloway, Shalini Vinod

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Farhannah AlySouthwest Sydney Clinical Campus, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-4674-1480
Joseph DescallarSouthwest Sydney Clinical Campus, University of New South Wales, Sydney, Australia.
Purnima SundaresanSydney West Radiation Oncology Network, WSLHD, Sydney, Australia.
Alexis Andrew MillerIllawarra Cancer Care Centre, ISLHD, Wollongong, Australia.
Lois HollowaySouthwest Sydney Clinical Campus, University of New South Wales, Sydney, Australia.
Shalini VinodSouthwest Sydney Clinical Campus, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0001-8075-6219

Funding

Australian Government Research Training Programme
6 · The paper itself

Abstract

purposeTo investigate treatment variations and outcomes between older (≥ 70 years) and younger (< 70 years) patients with mucosal head and neck squamous cell carcinoma (mHNSCC) treated with radiotherapy.

methodsA multicenter retrospective review of patients diagnosed from 2010 to 2018 was conducted. Patient, tumor, and treatment data were collected, including overall survival (OS) and progression-free survival (PFS). Multivariable analyses examined factors influencing standard-of-care (SOC) treatment, OS, and PFS.

resultsOf 1553 patients, 432 patients were ≥ 70 years. Older patients were significantly less likely to receive curative treatment, SOC, or concurrent systemic therapy. Age, marital status, ECOG status, stage, and subsite influenced SOC treatment. Three-year OS and PFS were lower in older patients. ECOG status, stage, subsite, and SOC treatment were significantly associated with OS and PFS. Older age and smoking status were significantly associated with lower OS but not PFS.

conclusionsOlder patients should be offered SOC treatment where appropriate for maximal disease control and survival.

Indexed as

Head and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesSurvival AnalysisSurvival RateTreatment Outcomegeriatric oncologyhead and neck squamous cell carcinomaradiotherapyretrospective studiessurvival

Identifiers

PMID42087331
PMCPMC13595478

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.