Evidence map›Paper›PMID 42087386›Full record

ReviewEuropean journal of clinical investigation2026

Lifelong Exercise as a Modulator of CD4

Bruna Spolador de Alencar Silva, Amanda Veiga Sardeli, Ricardo R Agostinete, Helena Batatinha, Alessandra Peres, José César Rosa-Neto, José Teixeira, Manuel J Coelho-E-Silva, Paulo J Oliveira, Fábio Santos Lira

Abstract readReview
In one paragraph

Review in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bruna Spolador de Alencar SilvaDepartment of Physical Education, Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente, Brazil.ORCID https://orcid.org/0000-0002-9085-9251
Amanda Veiga SardeliDepartment of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0009-0005-7323-5956
Ricardo R AgostineteLaboratory of Investigation in Exercise (LIVE), Department of Physical Education, Sao Paulo State University (UNESP), Presidente Prudente, Brazil.
Helena BatatinhaUniversity of North Carolina at Greensboro, Greensboro, North Carolina, USA.
Alessandra PeresRehabilitation Sciences Graduate Program, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
José César Rosa-NetoDepartment of Cell and Developmental Biology, University of São Paulo, São Paulo, Brazil.
José TeixeiraCNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Manuel J Coelho-E-SilvaUniversity of Coimbra, FCDEF, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-4512-7331
Paulo J OliveiraCNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0002-5201-9948
Fábio Santos LiraDepartment of Physical Education, Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Sao Paulo State University (UNESP), Presidente Prudente, Brazil.

Funding

Coordination for the Improvement of Higher Education Personnel 001European Commission 101080329National Council for Scientific and Technological Development 150760/2022-1National Council for Scientific and Technological Development 303650/2024-9PROPe UNESP 13/2022São Paulo Research Foundation 2021/11932-8São Paulo Research Foundation 2023/09216-8São Paulo Research Foundation 2025/23395-8
6 · The paper itself

Abstract

backgroundIt is commonly assumed that aging and chronic low-grade inflammation compromise adaptive immunity, particularly the function and metabolism of CD4

methodsThe current narrative review explores how lifelong physical exercise impacts CD4

resultsThis review suggests that lifelong exercise may reprogram CD4

conclusionsLifelong and early-life exercise may reprogram CD4

Indexed as

AgingCD4-Positive T-LymphocytesExerciseAdaptive ImmunityGlycolysisHumansImmunosenescenceInflammationOxidative PhosphorylationTh17 CellsT-Lymphocytes, RegulatoryAgingEnergy metabolismExerciseImmune functionImmunosenescence

Identifiers

PMID42087386
PMCPMC13144711

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.