Daily intake of cuminaldehyde-rich cumin essential oil improves cognitive function in healthy elderly Japanese adults: a randomized, double-blind, placebo-controlled pilot study.

Kengo Ito, Jieun Yoon, Kazunori Sasaki, Yuri Nakagawa, Hiroyuki Onda, Hiroko Isoda, Tomohiro Okura

Abstract readClinical Trial

In one paragraph

Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kengo ItoS&B FOODS Inc., Itabashi City, Tokyo, Japan.

Jieun YoonInstitute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.

Kazunori SasakiR&D Center for Tailor-Made QOL, University of Tsukuba, Tsukuba, Japan.

Yuri NakagawaS&B FOODS Inc., Itabashi City, Tokyo, Japan.

Hiroyuki OndaS&B FOODS Inc., Itabashi City, Tokyo, Japan.

Hiroko IsodaR&D Center for Tailor-Made QOL, University of Tsukuba, Tsukuba, Japan.

Tomohiro OkuraInstitute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To extend healthspan has risen demand to maintain cognitive function through the exploitation of bioactive compounds from natural sources. We assessed the effects of daily intake of cumin essential oil (CEO), primarily composed of cuminaldehyde, on cognitive function in the elderly. Methods: Thirty-eight participants (ages 65-86) were randomly assigned to either the CEO group ( Results: The analysis revealed a significant group × time interaction for the CEO group in psychomotor speed ( Conclusion: Overall, this study suggest that the daily intake of CEO, rich in cuminaldehyde, have a beneficial effect on cognitive function in the elderly. These findings provide foundational knowledge that could contribute to strategies aimed at extending the healthy life expectancy of older adults. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057216, identifier UMIN000050328.

Indexed as

anti-inflammatorycognitive functioncumincuminaldehydefunctional foodrandomized clinical trial

Identifiers

PMID42088310

DOI10.3389/fnut.2026.1784027

PMCPMC13135935

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.