Evidence map›Paper›PMID 42088441›Full record

ArticleInternational journal of biological sciences2026

Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex.

Sheng Zhang, Lei Tang, Yunzhou Pu, Yu You, Hongyu Chen, Yongqi Chen, Yanqing Huang, Xiaodie Liu, Qing Song, Qing Ji and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sheng ZhangGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Lei TangDepartment of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yunzhou PuDepartment of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yu YouChengdu University of Traditional Chinese Medicine, Chendu 610075, China.
Hongyu ChenDepartment of Oncology, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China.
Yongqi ChenDepartment of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yanqing HuangDepartment of Oncology, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China.
Xiaodie LiuDepartment of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Qing SongDepartment of Medical Oncology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Qing JiDepartment of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu YangShanghai Baoshan District Wusong Central Hospital (Zhongshan Hospital Wusong Branch, Fudan University), Shanghai 200940, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the leading cause of global cancer-related mortality, lung cancer has a particularly poor prognosis among non-small cell lung cancer (NSCLC) subtypes, which constitute 85% of cases and are frequently diagnosed at advanced stages. Through integrated pharmacological approaches, this study elucidates the novel anti-NSCLC mechanism of patchouli alcohol (PA), a low-toxicity sesquiterpene alcohol. We confirmed that compared with conventional chemotherapeutics, PA induced autophagic cell death in NSCLC models (

Indexed as

Autophagic Cell DeathCarcinoma, Non-Small-Cell LungGTP-Binding Protein alpha Subunits, Gi-GoLung NeoplasmsSesquiterpenesAnimalsAutophagyCell Line, TumorHumansMiceMolecular Docking SimulationGTP-Binding Protein alpha Subunits, Gi-Gopatchouli alcoholSesquiterpenesARRB1autophagic cell deathGNAI1non-small cell lung cancerpatchouli alcohol

Identifiers

PMID42088441
PMCPMC13137856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.