Evidence map›Paper›PMID 42088577›Full record

ArticleFrontiers in pharmacology2026

CXCL8 greatly enhances neutrophil extracellular traps formation induced by calcium crystals

Irene Fasciani, Maria De Lucia, Gemma Conte, Lucia Apparente, Ida Cerqua, Chayakorn Petchakup, Francesco Petragnano, Gabriella Aloisi, Giada Cremonesi, Nicola Detta and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Irene FascianiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Maria De LuciaPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Gemma ContePreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Lucia ApparentePreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Ida CerquaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Chayakorn PetchakupSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.
Francesco PetragnanoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Gabriella AloisiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Giada CremonesiPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Nicola DettaPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Han Wei HouSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.
Raffaele CapassoDepartment of Agricultural Sciences, University of Naples Federico II, Naples, Italy.
Rafael Cypriano DutraPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Riccardo BertiniATREIUS S.a.s., L'Aquila, Italy.
Andrea AraminiPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Marcello AllegrettiPreclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Roberto MaggioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Pier Giorgio Amendola *Preclinical Research, Dompé Farmaceutici S.p.a., L'Aquila, Italy.
Mario Rossi *Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophil extracellular traps (NETs) contribute to host defense but can also drive sterile inflammation and tissue injury. Among particulate inducers, monosodium urate and calcium crystals are potent triggers of NETosis. The role of the chemokine interleukin-8 (CXCL8) in NET formation, however, has remained controversial and context-dependent. Here we show that CXCL8 markedly amplifies NETosis induced by calcium carbonate (CaCO

Indexed as

calcium aggregatesCXCL8inflammationNETosis modelneutrophils

Identifiers

PMID42088577
PMCPMC13136156

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.