Evidence map›Paper›PMID 42088949›Full record

ArticleFrontiers in physiology2026

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection.

Sean Brennan, Samir Makwana, Shen Chen, Lauren R McGuinness, Moustafa Sweihi, Jacob A Whitmore, Mahmoud E Elghayesh, Christopher A Martin, Noorann Sheikh, Manish Patel and 4 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sean BrennanDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Samir MakwanaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Shen ChenDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Lauren R McGuinnessDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Moustafa SweihiDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Jacob A WhitmoreDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Mahmoud E ElghayeshDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Christopher A MartinDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Noorann SheikhDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Manish PatelDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Phoebe MalinDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.
Mark W SimsDepartment of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Caroline DartDepartment of Biochemistry, Cell and Systems Biology, University of Liverpool, Liverpool, United Kingdom.
Richard D RainbowDepartment of Cardiovascular and Metabolic Medicine & Liverpool Centre for Cardiovascular Sciences, University of Liverpool, Liverpool, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adenosine triphosphate (ATP)-sensitive potassium (K Methods: Patch-clamp recordings were used to investigate channel activity, in control cardiomyocytes, following adenosine or K Results: Cardioprotective stimuli increased Kir6.1 channel activity leading to action potential shortening, reduced Ca Discussion: These findings suggest that the two functionally distinct populations of ventricular K

Indexed as

ATP-sensitive potassium channelcardiomyocytescardioprotectionKATP channelsKir6.1

Identifiers

PMID42088949
PMCPMC13135945

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.