ArticleJACC. Asia2026
Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population.
Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Limitation of Using Pulmonary Artery Wedge Pressure to Screen Left Heart Disease.JACC. Asia · 2026Article
- You Can't Always Get What You Want: Sensitivity or Specificity in Pulmonary Hypertension Prediction.JACC. Asia · 2026Article
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18 authors.
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Abstract
backgroundNoninvasive prediction of postcapillary pulmonary hypertension (PH) is a useful clinical tool. However, existing scores are not well evaluated in Asian populations.
objectivesThis study aimed to develop a novel prediction score for postcapillary PH in an Asian cohort.
methodsA single-center retrospective cohort study was performed in patients who had undergone right heart catheterization from July 2018 to June 2022. Patients with an ejection fraction <50% or moderate or worse left valvular disease were excluded. Postcapillary PH was diagnosed with a mean pulmonary arterial pressure >20 mm Hg and pulmonary capillary wedge pressure (PCWP) >15 mm Hg. A novel logistic regression model (POISE [Prediction Of raISEd wedge pressures]) was developed, with validation by bootstrapping. Comparisons against the OPTICS and H2FPEF scores were performed. Sensitivity analysis was performed excluding patients with combined pre- and post-PH.
resultsA total of 266 patients were included, of whom 110 had a raised PCWP >15 mm Hg. Body mass index >30 (adjusted OR: 2.79; 95% CI: 1.42-5.47), atrial fibrillation (adjusted OR: 2.26; 95% CI: 1.01-5.02), E/e' ratio (adjusted OR: 1.058, 95% CI: 1.01-1.10), and left atrial index >34 cm
conclusionsThe high specificity and better performance (vis à vis existing scores) of POISE may help in identifying a subset of Asian patients with postcapillary PH, reducing the need of right heart catheterization. POISE is available as an online risk calculator.
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