ArticleJournal of clinical microbiology2026
Development and validation of a national reference material system for quality control of chikungunya virus nucleic acid detection assays.
Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
The absence of a World Health Organization (WHO) international standard for Chikungunya virus (CHIKV) nucleic acid testing has long impeded the comparability of diagnostic results across different assays and platforms. To address this critical gap in quality assurance, we developed and rigorously characterized a national reference material system consisting of a quantified standard and a validation panel for CHIKV molecular detection. These materials were developed using intact, inactivated CHIKV particles to closely mimic clinical extraction and amplification. The assigned value of the standard was determined through a robust multi-laboratory study using eight digital polymerase chain reaction (dPCR) platforms, yielding a traceable concentration of 7.60 ± 0.14 log
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