ArticleExperimental & applied acarology2026
High protective efficacy of a recombinant Fer2 vaccine against Dermacentor marginatus infestations.
Article in Experimental & applied acarology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dermacentor marginatus is an important disease vector in China, yet current control methods remain heavily reliant on chemical acaricides. This study evaluated the vaccine potential of Ferritin 2 from D. marginatus (DmFer2). The DmFer2 gene was cloned, expressed as a recombinant DmFer2 (rDmFer2) in a prokaryotic expression system, and subsequently used to immunize rabbits. Immunization elicited high anti-rDmFer2 antibody titers, which peaked at a detectable maximum of 1:25,600 on day 35, and significantly reduced tick fecundity and altered tick feeding kinetics in challenge trials. Specifically, rDmFer2 vaccination resulted in prolonged engorgement cycle (8.25% relative extension), and reductions in the oviposition rate (19.64%), egg mass weight (43.74%), and hatching rate (38.5%), leading to an overall anti-tick efficacy of 82.1%. These results demonstrate, for the first time, that rDmFer2 is a highly effective vaccine candidate against D. marginatus. Its protective effects are primarily attributed to disrupting tick iron metabolism and interfering with tick feeding dynamics, and provide a theoretical and experimental foundation for the development of sustainable tick control strategies.
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