Evidence map›Paper›PMID 42089951›Full record

ArticleClinical journal of gastroenterology2026

Rapid regression of advanced hepatic fibrosis in a patient with metabolic dysfunction-associated steatotic liver disease and severe obesity: a case report highlighting lifestyle-induced NETosis activation through serum proteomic analysis.

Toru Nakamura, Shigemune Bekki, Dan Nakano, Atsutaka Masuda, Keisuke Amano, Masahito Nakano, Takumi Kawaguchi

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Toru NakamuraDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. ntoru@kurume-u.ac.jp.ORCID http://orcid.org/0000-0002-0954-1191
Shigemune BekkiDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Dan NakanoDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Atsutaka MasudaDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Keisuke AmanoDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Masahito NakanoDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Takumi KawaguchiDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Funding

Japan Agency for Medical Research and Development JP24fk0210141Japan Agency for Medical Research and Development JP24fk0210149Japan Agency for Medical Research and Development JP24fk0210154Japan Society for the Promotion of Science JP24K11119Kurume University NoneMinistry of Health, Labour and Welfare JPMH23HC2002
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive condition linked to obesity and insulin resistance, potentially leading to cirrhosis. While lifestyle intervention is a primary treatment, the molecular mechanisms driving the regression of advanced fibrosis remain poorly understood. We report a man in his 30 s with severe obesity (BMI 35.2 kg/m

Indexed as

Extracellular TrapsFatty LiverLiver CirrhosisObesity, MorbidAdultCaloric RestrictionHistonesHumansLeukocyte ElastaseLife StyleMalePeroxidaseProteomicsHistonesLeukocyte ElastasePeroxidaseDietary and exercise therapyFibrosis regressionMetabolic dysfunction-associated steatotic liver disease (MASLD)Neutrophil extracellular traps (NETs)Proteomic analysis

Identifiers

PMID42089951

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.