Evidence map›Paper›PMID 42090294›Full record

ArticleOrganic letters2026

Functionality-Matched Semicarbazone Reagents Allow Access to X-ray Quality Crystals and Solids of Diverse Organic Molecules.

Emily R Sherman, Jeffrey S Johnson

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emily R ShermanDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States.
Jeffrey S JohnsonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States.ORCID 0000-0001-8882-9881

Funding

Synthesis of Bioactive Small Molecule Building BlocksR35GM118055 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jeffrey S Johnson · 2016 to 2026
$5.0M
NIGMS NIH HHS R35 GM118055
6 · The paper itself

Abstract

A flexible approach to crystalline compounds was developed: lipophilic structures of interest were connected to pro-crystalline semicarbazone reagents via copper-catalyzed azide-alkyne cycloaddition or Brønsted-Lowry acid-base reactions. A variety of lipophilic structures, including esters, carbamates, acids and amines were converted into crystalline solids as determined by powder X-ray diffraction (mp 134 to >240 °C). Single crystal X-ray diffraction revealed hydrogen-bond interactions between the semicarbazone and charged ammonium or acetate groups that may aid in ordering the crystals.

Identifiers

PMID42090294
PMCPMC13203372

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.