In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Maria KuzminaLaboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0000-0001-5373-7653 Srdjan GrusanovicLaboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0000-0001-5134-9630 Jiri BrezinaLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.
Flavian ThelenDepartment of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-9372-1995 Karolina VanickovaLaboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0000-0003-4708-6772 Mirko MilosevicLaboratory of Cellular Metabolism, Institute of Biotechnology of the Czech Academy of Sciences, Prumyslova 595, 252 50 Vestec, Prague-West, Czech Republic.
Irina Ribeiro BasLaboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0009-0003-3529-2533 Nataliia PavliuchenkoLaboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Prague, Czech Republic.ORCID 0009-0003-7942-8914 Sarka RuzickovaLaboratory of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Prague, Czech Republic.
Jakub RohlenaLaboratory of Cellular Metabolism, Institute of Biotechnology of the Czech Academy of Sciences, Prumyslova 595, 252 50 Vestec, Prague-West, Czech Republic.ORCID 0000-0001-5427-6502 Dominik FilippLaboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0000-0003-2506-9330 Katerina RohlenovaLaboratory of Cellular Metabolism, Institute of Biotechnology of the Czech Academy of Sciences, Prumyslova 595, 252 50 Vestec, Prague-West, Czech Republic.ORCID 0000-0003-3964-8472 Cesar Nombela-ArrietaDepartment of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-0415-259X Tomas BrdickaLaboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Prague, Czech Republic.ORCID 0000-0002-1560-4398 Meritxell Alberich-JordaLaboratory of Hemato-oncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Prague, Czech Republic.ORCID 0000-0002-8093-641X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Hematopoietic stem and progenitor cells (HSPCs) are localized within specialized niches of the bone marrow (BM). However, during hematological disorders or infections, the functionality of these cells in the BM is compromised, leading to extramedullary hematopoiesis (EMH). Chronic inflammation drives EMH, yet its impact on HSPCs outside the BM is poorly understood. Using a mouse model of chronic autoinflammatory disease, we demonstrated the presence of extramedullary HSPCs in blood, spleen, and inflamed tails and paws. Single-cell transcriptomics revealed a unique expression profile in extramedullary HSCs, with significant up-regulation of
Indexed as
Hematopoiesis, ExtramedullaryHematopoietic Stem CellsInflammationT-Lymphocytes, RegulatoryAnimalsAntigen-Presenting CellsChronic DiseaseDisease Models, AnimalMice
Identifiers
PMID42090507
PMCPMC13148345
What Socratic holds
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