Observational studyRevista medica del Instituto Mexicano del Seguro Social2026
[Neutrophil-lymphocyte ratio and retinopathy in patients with type 2 diabetes mellitus].
Observational study in Revista medica del Instituto Mexicano del Seguro Social, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetic retinopathy is a complication of type 2 diabetes mellitus. Inadequate glycemic control can promote a chronic inflammatory state. The Neutrophil-lymphocyte ratio has been used as a marker of systemic inflammation. Objective: To correlate the Neutrophil-lymphocyte ratio with the degree of retinopathy in patients with type 2 diabetes mellitus. Material and methods: Cross-sectional and analytical study. Patients with type 2 diabetes mellitus were included. The degree of retinopathy, glucose level, HbA1C, and neutrophil and lymphocyte counts were investigated to calculate the Neutrophil-lymphocyte ratio. To test the hypothesis, Fisher's exact test, Mann Whitney U, Kruskal-Wallis, and Spearman's Rho were used in the statistical analysis. A p < 0.05 was considered statistically significant. Results: 50 patients were included; their age was 65 ± 10 years. The mean Neutrophil-lymphocyte ratio was 2.5 ± 1.1. Mild nonproliferative retinopathy was present in 56% of the patients, moderate nonproliferative retinopathy in 14%, and high-risk proliferative retinopathy in 30%. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of retinopathy (r = 0.532) (p = 0.000). Conclusions: Type 2 diabetes mellitus patients with a higher degree of diabetic retinopathy had a higher Neutrophil-lymphocyte ratio. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of diabetic retinopathy.
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