Evidence map›Paper›PMID 42090969›Full record

ArticleMolecular pharmacology

Ca

Tiffany S Dwyer, Annadka Shrinidhi, Sadikshya Aryal, Martin W Berchtold, Mads Munk, Amanda H Klein, Wendy A Koss, Daniel P Flaherty, Val J Watts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiffany S DwyerDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana.
Annadka ShrinidhiDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana.
Sadikshya AryalDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana.
Martin W BerchtoldDepartment of Biology, University of Copenhagen, Nørregade, Copenhagen, Denmark.
Mads MunkDepartment of Biology, University of Copenhagen, Nørregade, Copenhagen, Denmark.
Amanda H KleinDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York; Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, Duluth, Minnesota.
Wendy A KossPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana; Office of the Executive Vice President for Research, Purdue University, Purdue University, West Lafayette, Indiana.
Daniel P FlahertyDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana; Purdue Institutes for Drug Discovery, Cancer Research, and Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana. Electronic address: dflaher@purdue.edu.
Val J WattsDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana; Purdue Institutes for Drug Discovery, Cancer Research, and Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana. Electronic address: wattsv@purdue.edu.

Funding

KATP Channels as Downstream targets of adenylyl cyclases during opioid tolerance and withdrawalR01DA051876 · NIDA · UNIVERSITY OF MINNESOTA · PI KLEIN, AMANDA HELEN · 2021 to 2025
$2.9M
Pharmacological validation of adenylyl cyclase 1 as a drug target for chronic painR01NS119917 · NINDS · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK, WATTS, VAL J · 2021 to 2025
$2.0M
NIDA NIH HHS R01 DA051876NINDS NIH HHS R01 NS119917
6 · The paper itself

Abstract

Adenylyl cyclase 1 (AC1) plays an integral role in the excitatory signaling in the anterior cingulate cortex underlying chronic pain pathophysiology. Upon chronic nociceptive input, sustained Ca

Indexed as

Adenylyl Cyclase InhibitorsAdenylyl CyclasesAnalgesics, Non-NarcoticCalciumCalmodulinChronic PainAnimalsHEK293 CellsHumansInflammationMaleMiceReceptors, Opioid, kappaadenylyl cyclase 1Adenylyl Cyclase InhibitorsAdenylyl CyclasesAnalgesics, Non-NarcoticCalciumCalmodulinReceptors, Opioid, kappaAdenylyl cyclaseCalmodulinChronic painCyclic AMPDrug discoveryPyrazolopyrimidinone amine

Identifiers

PMID42090969
PMCPMC13359510

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.