Evidence map›Paper›PMID 42091690›Full record

ArticleCellular & molecular immunology2026

USP21 drives immune evasion in colorectal cancer via deubiquitination and stabilization of β-catenin.

Mantang Zhou, Anqi Han, Bingjie Guan, Menghua Zhou, Changsong Zheng, Jianjun Xiang, Yushuai Mi, Bowen Xie, Peng Lian, Sanjun Cai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mantang Zhou *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0008-8374-211X
Anqi Han *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bingjie Guan *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-3709-291X
Menghua Zhou *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-3396-5269
Changsong Zheng *Department of Integrated Traditional Chinese and Western Medicine for Anorectal Diseases, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Shandong, China.
Jianjun Xiang *Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yushuai MiDepartment of Gastrointestinal Surgery, the Second Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China.
Bowen XieDepartment of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peng LianDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Sanjun CaiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Xinxiang LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Jieyun ZhangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Dr_JYZ@outlook.com.
Dawei LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. li_dawei@fudan.edu.cn.
Dongwang YanDepartment of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yandw70@163.com.
Senlin ZhaoDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. sunshinezsl1989@163.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82372643National Natural Science Foundation of China (National Science Foundation of China) 82503175Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 25ZR1401303Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 25ZR1402438
6 · The paper itself

Abstract

The efficacy of immune checkpoint blockade (ICB) therapy in colorectal cancer (CRC) remains limited. Thus, elucidating the molecular mechanisms underlying tumor immune evasion and identifying novel predictive biomarkers are critical for improving immunotherapy outcomes in CRC patients. Here, we report that ubiquitin-specific peptidase 21 (USP21) is overexpressed in tumor tissues from CRC patients who fail to respond to immunotherapy and that its expression is correlated with CD8

Indexed as

beta CateninColorectal NeoplasmsImmune EvasionTumor EscapeUbiquitinationUbiquitin ThiolesteraseAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansMiceMice, Inbred C57BLProtein Stabilitybeta CateninUbiquitin ThiolesteraseColorectal CancerImmune EvasionImmunotherapyUbiquitin-specific protease 21β-catenin

Identifiers

PMID42091690
PMCPMC13222366

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.