Evidence map›Paper›PMID 42091966›Full record

ArticleScientific reports2026

Hypericin-loaded small extracellular vesicles increase photodynamic therapy and remodel miRNA-mRNA axes in AGS gastric cancer cells.

Seyedeh Faegheh Hoseini, Abbas Ali Dehpour, Roya Bishehkolaei, Bahman Eslami Jadidi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seyedeh Faegheh HoseiniDepartment of Biology, QaS.C, Islamic Azad University, Qaemshahr, Iran.
Abbas Ali DehpourDepartment of Biology, QaS.C, Islamic Azad University, Qaemshahr, Iran. dehpour@iau.ac.ir.
Roya BishehkolaeiDepartment of Biology, QaS.C, Islamic Azad University, Qaemshahr, Iran. roya.bishehkolaei@iau.ac.ir.
Bahman Eslami JadidiDepartment of Biology, QaS.C, Islamic Azad University, Qaemshahr, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer remains a cause of cancer mortality, and there is a need for locally controllable therapies that limit systemic toxicity and overcome heterogeneous responses. Photodynamic therapy (PDT) is attractive, yet efficacy is constrained by limited intracellular availability of photosensitizers. We tested whether small extracellular vesicles (sEVs) enhance hypericin (HYP) delivery and PDT responses in AGS cells, and whether cytotoxicity aligns with transcript and epigenetic remodeling. Human sEVs were loaded with HYP by probe sonication and characterized by DLS/ELS, TEM, and CD9/CD63/CD81 flow profiling. Cells were assigned to untreated, light-only, sEV-only (+ light), free HYP (dark), free HYP + PDT, sEV-HYP (dark), or sEV-HYP + PDT; irradiation used 590 nm (3 J/cm²). sEV-HYP + PDT left-shifted dose-response and reduced IC₅₀ at 24 h (9.8 vs. 12.9 µg/mL) and 48 h (5.1 vs. 8.9 µg/mL). sEV delivery accelerated intracellular deposition: at 4 h, HYP

Indexed as

Extracellular VesiclesMicroRNAsPerylenePhotochemotherapyPhotosensitizing AgentsRNA, MessengerStomach NeoplasmsAnthracenesApoptosisCell Line, TumorGene Expression Regulation, NeoplasticHumansAnthraceneshypericinMicroRNAsPerylenePhotosensitizing AgentsRNA, MessengerApoptotic cell deathChromatin immunoprecipitationExosome-based drug deliveryPhototoxicityPromoter DNA methylationReactive oxygen species

Identifiers

PMID42091966
PMCPMC13333953

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.