ArticleScientific reports2026
Detecting early structural and functional myocardial alterations in patients with repaired tetralogy of fallot: a prospective MRI study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with repaired tetralogy of Fallot (rTOF), right ventricular (RV) fibrosis has been associated with ventricular tachycardia, heart failure, and sudden cardiac death. Here, we aimed to identify links between diffuse myocardial fibrosis and regional mechanical dysfunction by cardiac magnetic resonance imaging (CMR) in rTOF. Clinical CMR was extended in 17 consecutive rTOF patients (median age 20 years, 4 females) to include biventricular native T1 (nT1) mapping as indicator of diffuse fibrosis, and tissue phase mapping (TPM) for quantification of biventricular segmental, directional systolic/diastolic myocardial velocities. Patients demonstrated smaller peak velocities than healthy volunteers in both ventricles (e.g. LV-base circumferential peak-systolic velocity: median [IQR] -0.9 [1.5] vs. -3.0 [1.2] cm/s, p < 0.001). RV peak velocities were reduced even in patients with normal RV ejection fraction (e.g. RV-mid long-axis peak-diastolic velocity: -3.3 [1.2] vs. -6.9 [1.8] cm/s, p = 0.001). Global LV nT1 was higher in patients versus controls (1029 [48] vs. 993 [28] ms, p = 0.013). Within the rTOF group, fibrosis in lateral LV correlated with shorter time-to-peak-velocity (TTP), whereas fibrosis in inferior RV correlated with longer TTP. Therefore, in rTOF TPM facilitates early diagnosis of impaired systolic and diastolic myocardial function while diffuse fibrosis has differential effects on RV and LV mechanics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.