Evidence map›Paper›PMID 42092139›Full record

ArticleNature2026

A brain reward circuit inhibited by next-generation weight-loss drugs in mice.

Elizabeth N Godschall, Taha Bugra Gungul, Isabelle R Sajonia, Aleyna K Buyukaksakal, Orien Li, Sophia Ogilvie, Austin B Keeler, Guilian Tian, Yu Shi, Omar Koita and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Elizabeth N Godschall *Department of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-9719-5048
Taha Bugra Gungul *Department of Biology, University of Virginia, Charlottesville, VA, USA.
Isabelle R Sajonia *Department of Biology, University of Virginia, Charlottesville, VA, USA.
Aleyna K BuyukaksakalDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Orien LiDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Sophia OgilvieDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Austin B KeelerDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-6148-0891
Guilian TianDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Yu ShiDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Omar KoitaDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Chloe Xinzhu GuoDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Tyler C J DeutschDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA.
Eric J SteacyDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0009-0009-6523-9999
Maisie CrookDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
YuChen ZhangNeuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.
Nicholas J ConleyDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Gulsun MemiDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-4897-6307
Addison N WebsterDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
O Yipkin CalhanDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Weile LiuDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Amani AkkoubDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Karan MalikDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Kaleigh I WestDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Sara Michel-LeDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Arun KarthikeyanDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Grace van GervenDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Olivia A Dell'AglioDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Kevin T BeierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4934-1338
Larry S ZweifelDepartment of Pharmacology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3465-5331
Manoj K PatelDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USA.
John N CampbellDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-3943-8312
Christopher D DeppmannDepartment of Biology, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.ORCID http://orcid.org/0000-0002-6591-1767
Ali D GülerDepartment of Biology, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.ORCID http://orcid.org/0000-0001-8218-850X

Funding

Role of CACHD1 in the development of temporal lobe epilepsy and absence epilepsyR01NS120702 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$399k
Role of brainstem cardiorespiratory neurons in SUDEPR01NS122834 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$359k
NINDS NIH HHS R01 NS120702NINDS NIH HHS R01 NS122834
6 · The paper itself

Abstract

Glucagon-like peptide 1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes; however, established peptide-based therapies require injections and are complex to manufacture

Indexed as

Anti-Obesity AgentsBrainFeeding BehaviorGlucagon-Like Peptide-1 Receptor AgonistsNeural PathwaysRewardWeight LossAmygdalaAnimalsDopamineEatingFemaleGlucagon-Like Peptide-1 ReceptorHomeostasisHumansMaleAnti-Obesity AgentsDopamineGlp1r protein, mouseGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor Agonists

Identifiers

PMID42092139
PMCPMC13293854

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.