Engineered human plasma-derived cryogels as a multifunctional scaffold to promote diabetic wound healing.

Yueming Zhao, Jiajun Hu, Kairui Duan, Tingting Li, Mian Lin, Bae Hoon Lee

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yueming ZhaoSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, China.

Jiajun HuDepartment of Periodontics, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

Kairui DuanZhejiang Key Laboratory of Soft Matter Biomedical Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.

Tingting LiZhejiang Key Laboratory of Soft Matter Biomedical Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.

Mian LinZhejiang Key Laboratory of Soft Matter Biomedical Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.

Bae Hoon LeeSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds, characterized by prolonged inflammation and impaired tissue regeneration, represent a critical clinical challenge, particularly in diabetic patients. Conventional therapies often fail to address the multifaceted demands of healing, which requires integrated structural support, bioactive signaling, and immune modulation. To overcome these limitations, we engineered a macroporous cryogel scaffold from methacryloyl-modified human plasma (PlasmaMA) via cryopolymerization. This process transforms the native bioactivity of plasma into a stable, biomimetic extracellular matrix (ECM)-like architecture with tunable mechanical resilience and degradability. The resulting PlasmaMA cryogel inherently retains essential human ECM proteins (e.g., albumin, fibronectin, fibrinogen) and growth factors (e.g., VEGF), which collectively facilitate robust cell adhesion, sustain pro-regenerative signaling, and promote angiogenesis.

Indexed as

Diabetic woundsEndogenous VEGFEngineered cryogelsHuman plasmaMultifunctional properties

Identifiers

PMID42093734

DOI10.1016/j.mtbio.2026.103151

PMCPMC13141794

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.