Evidence map›Paper›PMID 42094166›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Cutaneous Microvascular Functional Reserve is Associated with Kidney Function and Histopathologic Injury in CKD: The MAP-CKD Study.

Armin Ahmadi, Masfiqur Rahaman, Amol Harsh, Jason Yang, Basma Ghanim, Subhasis Dasgupta, Robert N Weinreb, Tauhidur Rahman, Alfons Jhm Houben, Joachim H Ix and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Armin AhmadiDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.ORCID 0000-0002-7711-2356
Masfiqur RahamanHalıcıoğlu Data Science Institute, University of California San Diego, La Jolla, California, USA.
Amol HarshMohamed bin Zayed University of Artificial Intelligence, Abu Dhabi, United Arab Emirates.
Jason YangDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Basma GhanimDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Subhasis DasguptaSan Diego Supercomputer Center, University of California San Diego, La Jolla, California, USA.
Robert N WeinrebViterbi Family, Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, San Diego, California, USA.
Tauhidur RahmanHalıcıoğlu Data Science Institute, University of California San Diego, La Jolla, California, USA.
Alfons Jhm HoubenDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID 0000-0002-1747-8452
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.ORCID 0000-0002-8084-9869
Rakesh MalhotraDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Microvascular dysfunction is a key contributor to the development and progression of chronic kidney disease (CKD), yet direct and reproducible assessment of microvascular function in clinical CKD populations remains limited. Laser Doppler flowmetry (LDF) provides a noninvasive, dynamic assessment of skin microvascular blood flow and may serve as a surrogate measure of systemic microvascular health. However, the extent to which LDF-derived measures relate to kidney function, proteinuria, and kidney histopathology in CKD remains unclear. Methods: We assessed cutaneous microvascular function in 150 participants with CKD (estimated glomerular filtration rate [eGFR] <90 mL/min/1.73 m Results: Among 150 CKD participants, the mean (SD) age was 64 (14) years, 46% were female, 38% had diabetes, and 83% had hypertension. The mean eGFR was 42 (21) mL/min/1.73 m Conclusion: In persons with CKD, elevated resting perfusion and impaired microvascular functional reserve were associated with lower eGFR. These findings suggest that LDF-derived measures capture clinically relevant alterations in systemic microvascular function and may serve as a noninvasive biomarker of kidney function and underlying histopathologic injury in CKD.

Identifiers

PMID42094166
PMCPMC13142588

What Socratic holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.