Evidence map›Paper›PMID 42094482›Full record

ArticlebioRxiv : the preprint server for biology2026

PPM1B utilizes a trinuclear metal architecture for phosphatase activity.

Reece P Stevens, Viktoriya Solodushko, Andrzej Wierzbicki, Thomas C Rich, Mikael F Alexeyev, Marlo K Thompson, Madeline Stone, Camryn Hall, Althea deWeever, Sarah L Sayner and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Reece P StevensDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Viktoriya SolodushkoDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Andrzej WierzbickiDepartment of Chemistry, University of South Alabama, Mobile, AL, USA.
Thomas C RichDepartment of Pharmacology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Mikael F AlexeyevDepartment of Physiology and Cell Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Marlo K ThompsonDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Madeline StoneDepartment of Physiology and Cell Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Camryn HallDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Althea deWeeverDepartment of Pediatrics and Division of Neonatology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Sarah L SaynerDepartment of Physiology and Cell Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Troy StevensDepartment of Physiology and Cell Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Joel AndrewsDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Aishwarya PrakashDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Richard E HonkanenDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
Ji Young LeeDepartment of Physiology and Cell Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.
E Alan SalterDepartment of Chemistry, University of South Alabama, Mobile, AL, USA.
Mark R SwingleDepartment of Biochemistry and Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, Mobile, AL, USA.

Funding

Acidosis in pulmonary endothelial injury and repairR01HL160988 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Ji Young Lee · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL160988
6 · The paper itself

Abstract

The metal-dependent protein phosphatase (PPM/PP2C) family regulates innate immune and cell death pathways through reversible phosphorylation. Although these enzymes contain a conserved third Mg

Indexed as

innate immune signalingmetal-dependent catalysisPhosphatasePPM1Bthree-metal chemistrytrinuclear metal center

Identifiers

PMID42094482
PMCPMC13142519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.