Evidence map›Paper›PMID 42094501›Full record

ArticlebioRxiv : the preprint server for biology2026

Aged Tendons Have Impaired Mechanosensitivity and Lower Thresholds for Injury under Dynamic Compression.

Samuel J Mlawer, Brianne K Connizzo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samuel J MlawerDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, United States.
Brianne K ConnizzoDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, United States.ORCID 0000-0002-7818-0537

Funding

Innate and Hormone-Mediated Sex Differences in Extracellular Matrix RemodelingR35GM151127 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Brianne Kathryn Connizzo · 2023 to 2026
$1.6M
Development of In Vitro Compression-Induced Rotator Cuff Injury Model: Aging and Inflammation in Tendon DegenerationR00AG063896 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CONNIZZO, BRIANNE KATHRYN · 2021 to 2023
$830k
NIA NIH HHS R00 AG063896NIGMS NIH HHS R35 GM151127
6 · The paper itself

Abstract

Rotator cuff tendinopathy is highly prevalent in aging populations, yet the mechanisms leading to age-dependent tendon degeneration are not well understood. In addition to tensile loading, tendons are subjected to compressive forces at certain anatomical sites (e.g., Achilles, rotator cuff), where altered adaptive responses may contribute to degenerative remodeling. The objective of this study was to investigate age-related differences in tendon responses to dynamic compressive loading using an

Indexed as

AgingCompressive LoadingECM RemodelingTendon

Identifiers

PMID42094501
PMCPMC13142372

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.