ArticleTheranostics2026
CIAPIN1 functions as a redox-sensitive transcriptional repressor of
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Phenotypic switching in vascular smooth muscle cells (VSMCs) is a major driver of pathological vascular remodeling, including atherosclerosis and restenosis. Although p53 is a key regulator of VSMC homeostasis, the precise molecular mechanisms responsible for suppressing p53 expression during growth factor-induced phenotypic transitions remain incompletely understood. The present study identifies cytokine-induced apoptosis inhibitor 1 (CIAPIN1) as a novel redox-sensitive regulator of the p53 signaling axis. Methods: Primary cultured VSMCs and a rat carotid balloon injury model were used to investigate the role of CIAPIN1 in VSMC dynamics. CIAPIN1 expression was modulated using both gain- and loss-of-function approaches. The interaction between CIAPIN1 and the Results: In human atherosclerotic lesions, CIAPIN1 expression was markedly upregulated, whereas Conclusions: CIAPIN1 functions as a redox-sensitive transcriptional repressor of
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